Cisplatin nrf2

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August undefined, 2024

WebSep 1, 2024 · Cisplatin for injection is a cytotoxic drug. Follow applicable special handling and disposable procedures. 1 Reconstitution Reconstitute 50 mg vials with 50 mL of Sterile Water for Injection, USP. Each mL of the resulting solution will contain 1 mg of Cisplatin for injection. Reconstitution results in a clear or colorless to slight yellow solution. WebCisplatin is a platinum-based chemotherapeutic that has long since been effective against a variety of solid-cancers, substantially improving the five-year survival rates for cancer patients. Its use has also historically been limited by its adverse drug reactions, or cisplatin-induced toxicities (CITs). Of these reactions, cisplatin-induced nephrotoxicity (CIN), …

Leonurine alleviates ferroptosis in cisplatin-induced acute kidney ...

WebAbstract: ObjectiveTo investigate the effect of cisplatin on the protein expression and nuclear translocation of Nrf2, and on the changes of autophagy and apoptosis in HeLa human cervical cancer cells. MethodsAfter the HeLa human cervical cancer cells were treated with different concentrations of cisplatin(0, 2.5, 5 and 10 μmol/L), MTT assay … css button attributes

Fascin2 regulates cisplatin-induced apoptosis in NRK-52E cells

WebApr 1, 2024 · Alginate oligosaccharide is the depolymerized product of alginate, a natural extract of brown algae, which is associated with beneficial health effects. Here, we aimed to investigate the mechanism via which alginate oligosaccharides improve kidney oxidative damage and liver inflammation induced by cisplatin chemotherapy via the gut … WebApr 12, 2024 · In addition, after the combined action of cisplatin and Nrf2 activator, mitochondrial internal ROS in HEI-OC1 cells and cochlear hair cells remain unchanged during the activation of Nrf2, while the total intracellular ROS accumulation is significantly reduced (Zhang et al., 2024), suggesting that Nrf2 activation is not related to the … WebThe IC 50 s of Halofuginone (1, 10, 100, 1000 nM; 24 hours) for NRF2 protein are 22.3 and 37.2 nM in KYSE70 and A549 cells, respectively. The IC 50 of Halofuginone for global protein synthesis is 22.6 and 45.7 nM in KYSE70 and A549 cells, respectively. ... (0.25 mg/kg, intraperitoneally injected, every day) or cisplatin alone. Combined ... css button animations generator

The balance between NRF2/GSH antioxidant mediated …

CCT4 knockdown enhances the sensitivity of cisplatin by …

WebDec 18, 2016 · Nrf2 inhibition attenuates artesunate resistance in cisplatin-resistance HNC cells. Artesunate (Arts) selectively kills HNCs but not normal cells viathe induction of iron … WebAug 14, 2010 · Key findings: Cisplatin caused a significant decrease in the expression nuclear levels of NF-E2-related factor-2 (Nrf2), heme oxygenase-1(HO-1), and an increase in the levels of nuclear factor-kappa B (NF-kappaB p65) and 4-hydroxynonenal (HNE) an oxidative stress marker. EGCG supplementation significantly improved the changes … css button as a linkWebInterestingly, CCT4 knockdown enhanced the sensitivity of KYSE150 cells to DDP by regulating AMPK/AKT/Nrf2 signaling pathway and inhibiting glycolysis ability. Taken together, our results indicate that targeting CCT4 may be a therapeutic target in ESCC patients, which provides a theoretical basis to enhance the sensitivity of DDP in ESCC. css button border style

"WebDec 26, 2024 · We examined the preventive effect of α-lipoic acid (LA) on cisplatin-induced toxicity via its antioxidant effects on in vitro and ex vivo culture systems. To elucidate the mechanism of the antioxidant activity of LA, NRF2 was inhibited using NRF2 siRNA, and the change in antioxidant activity of LA was characterized. " - Cisplatin nrf2

Cisplatin nrf2

The role of Nrf2 in acute kidney injury: Novel molecular mechanisms …

WebJun 7, 2024 · Importantly, restoring Nrf2 signaling overturned ATF3-mediated ferroptosis and cisplatin resistance. Conclusion: ATF3 may sensitize GC cells to cisplatin by induction of ferroptosis via blocking Nrf2/Keap1/xCT signaling, supporting a promising therapeutic approach for overcoming chemoresistance in GC. WebJul 31, 2024 · Radiation-induced intestinal injuries (RIII) commonly occur in patients who suffer from pelvic or abdominal cancer. Nuclear factor-erythroid 2-related factor 2 (Nrf2) is a key transcriptional regulator of antioxidant, and the radioprotective role of Nrf2 is found in bone marrow, lung, and intestine, etc. Here, we investigated the effect of Nrf2 knockout …

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WebMar 15, 2014 · Cisplatin resistance is a major problem affecting ovarian carcinoma treatment. NF-E2-related factor 2 (Nrf2), a nuclear transcription factor, plays an … WebSep 15, 2024 · Cisplatin Injection (cisplatin injection (cisplatin (cisplatin injection) injection) ) is a sterile aqueous solution, available in 50, 100 and 200 mL multiple dose …

WebFeb 2, 2024 · Recently, a large number of articles have found that agents including edaravone and epigallocatechin-3-gallate (EGCG) prevented the development of … WebNov 11, 2024 · These data indicated that farrerol effectively inhibited cisplatin-induced inflammation and renal fibrosis by activating Nrf2 and PINK1/Parkin-mediated mitophagy, which provides a potential novel therapeutic target for CKD. Keywords: chronic kidney disease, mitophagy, Nrf2, PINK1, acute kidney injury Go to: Introduction

WebMay 1, 2024 · Nrf2 activation can protect cells against side effects of chemotherapeutic agents. • Cisplatin (CP) inhibits cancer progresion via inducing DNA damage and … WebThere is accumulating evidence that breast cancer 1 (BRCA1), sirtuin 1 (SIRT1), and epidermal growth factor receptor (EGFR) help to modulate cisplatin cytotoxicity. The role of dynamic crosstalk amon

WebDec 1, 2024 · Cisplatin is a chemotherapeutic drug that suppresses tumour's growth. • Cisplatin’s effectiveness is limited as it causes liver toxicity. • Various natural antioxidants protect against cisplatin-induced hepatotoxicity. • Hepatoprotective mechanisms are antioxidant, anti-inflammatory, and anti-apoptosis.

WebAug 20, 2024 · The unsupervised heat map analysis showed that Nrf2 target genes SOD2, SLC3A1, AKRC1, GCLC, HO-1, NQO1, and SOD1 were highly upregulated in the cisplatin-resistant tumor cells compared to the ... css button border-radiusWebCisplatin is a chemotherapy medication used to treat a wide range of cancers. A common side effect of cisplatin is myelosuppression. Research suggests that oxidative damages are strongly and consistently related to myelosuppression during cisplatin treatment. ω-3 polyunsaturated fatty acids (PUFAs) can enhance the antioxidant capacity of cells. css button bootstrap 5WebMar 18, 2024 · Cisplatin is a widely applied therapeutics for the treatment of osteosarcoma. However, its clinical applications have been hindered due to low efficacy and … css button before afterWebKey results: Nrf2 deletion induced ferroptosis-related protein expression and iron accumulation in vivo, aggravating cisplatin-induced acute kidney injury. Leonurine activated Nrf2 and prevented iron accumulation, lipid peroxidation and ferroptosis in vitro, being abolished in siNrf2-treated cells. css button border when clickedWebApr 1, 2024 · Alginate Oligosaccharide Alleviated Cisplatin-Induced Kidney Oxidative Stress via Lactobacillus Genus-FAHFAs-Nrf2 Axis in Mice Alginate Oligosaccharide Alleviated Cisplatin-Induced Kidney Oxidative Stress via Lactobacillus Genus-FAHFAs-Nrf2 Axis in Mice Front Immunol. 2024 Apr 1;13:857242. doi: 10.3389/fimmu.2024.857242. … ear cuff aristocrazyWebMay 1, 2024 · This was associated with inhibition of Nrf2 defense pathway. Moreover, cisplatin increased the expression of pro-inflammatory mediators in the kidney tissues. … css button border typesWebFeb 2, 2024 · Recently, a large number of articles have found that agents including edaravone and epigallocatechin-3-gallate (EGCG) prevented the development of cisplatin-related brain inflammation and oxidative damage by up-regulating the gene expression level of the Nrf2/HO-1 pathway and preventing the cisplatin-induced NF-κB activation … earcuff cadena